Adrenal and circulating small non-coding RNAs in the regulation of the neuroendocrine stress response
Prof. Dr. Alon Chen
Department of Stress Neurobiology and Neurogenetics
Max Planck Institute of Psychiatry
Dr. med. Anna Riester (nee. Hill)
Medical Clinic and Policlinic IV
Hospital of the Ludwig-Maximilians-Universität Munich
(I) Establish small ncRNA profiles, using small ncRNA sequencing, in adrenals and blood samples obtained from ACTH-independent and ACTH-dependent Cushing’s patients and healthy controls.
(II) Investigate polyamines in Cushing’s syndrome and their regulation by small ncRNAs.
(III) Confirm the predicted ‘microRNA-Target’ interactions in vitro.
(IV) Develop a mouse model to test the causal effects of alterations of specific small ncRNA expression levels on behaviour, physiology and gene expression.