Project B14 – 1st funding period

Identification and functional characterisation of genetic contributors to primary aldosteronism

Hier sollte ein Bild von Felix Beuschlein and Martin Reincke, Projekt B14, SFB/TRR 205 zu sehen sein.

Prof. Dr. med. Felix Beuschlein

felix.beuschlein[at]med.uni-muenchen.de
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München

Prof. Dr. med. Martin Reincke

martin.reincke[at]med.uni-muenchen.de
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München

www.erc-papa.eu ERC PAPA (Pathophysiology of Primary Aldosteronism)

Scientific staff:

Miriam Peters – Postdoc
Ariadni Spyroglou – PI
Johanna Döring – TA

Project Description

Project B14 deals with the identification of genes that contribute to bilateral adrenal hyperplasia (BAH), which causes primary aldosteronism. Key somatic mutations in a few genes have already been identified for aldosterone producing adenomas (APA), the second cause of primary aldosteronism. The project aims to close this gap by investigating candidate genes in mouse lines with detailed phenotypic and genetic characterization. Those will be compared to human surgical samples and can be further utilized in pharmacological approaches for treatment.

Aims

(I) Determine the endocrine and molecular phenotype of remaining N-ethyl-N-nitrosourea (ENU) generated mouse lines.

(II) Determine genetic contributor for hyperaldosteronism.

(III) Investigate functional interrelation between candidate gene and aldosterone secretion.

(IV) Investigate aldosterone synthase Cyp11b2 independent mechanisms of aldosterone oversecretion.