Project B17

Here is supposed to be a picture of the Project B17 of the CRCTRR 205
Marily Theodoropoulou and Martin Reincke


Prof. Dr. med. Martin Reincke
Department Director, Professor of Internal
Medizinische Klinik und Pliklinik IV
Klinikum der Ludwig-Maximilians-Universität Munich

Prof. Dr. rer. nat. Marily Theodoropoulou
W2 Professor of Neuroendocrinology
Medical Clinic and Policlinic IV, Ludwig-Maximilians-Universität Munich

Molecular pathology and treatment of Cushing’s disease
(I) Define the role of ubiquitin specific protease 8 (USP8) in the corticotroph tumour response to the glucocorticoid feedback from the adrenals and its implication on the development of Nelson’s syndrome tumours.
(II) Explore the genetic causes of corticotrophinoma tumour formation and glucocorticoid resistance using whole genome sequencing in both Cushing’s disease and Nelson’s syndrome.
(III) Identify new therapeutics that sensitize to glucocorticoids and limit hormone hypersecretion and tumour growth in Cushing’s disease and Nelson’s syndrome