Projekt A08

Hier sollte ein Bild von Alon Chen, Projekt A08, SFB/TRR 205 zu sehen sein.

Prof. Dr. Alon Chen
Department of Stress Neurobiology and Neurogenetics
Max Planck Institute of Psychiatry Munich

Anna Riester, Clinician Scientist, Adrenal Research CRC/TRR205

Dr. med. Anna Riester (nee. Hill)
Resident, PostDocMedical Clinic and Policlinic IV
Hospital of the Ludwig-Maximilians-Universität Munich

Adrenal and circulating small non-coding RNAs in the regulation of the neuroendocrine stress response

(I) Establish small ncRNA profiles, using small ncRNA sequencing, in adrenals and blood samples obtained from ACTH-independent and ACTH-dependent Cushing’s patients and healthy controls.

(II) Investigate polyamines in Cushing’s syndrome and their regulation by small ncRNAs.

(III) Confirm the predicted ‘microRNA-Target’ interactions in vitro.

(IV) Develop a mouse model to test the causal effects of alterations of specific small ncRNA expression levels on behaviour, physiology and gene expression.