Our Clinician Scientist Profile: Irina Chifu

Irina Chifu, Clinician Scientist, Adrenal Research CRC/TRR205

Irina Chifu     

University Hospital of Würzburg     

State exam: 2014, University Hospital “Gr. T. Popa” Iasi, Romania

Diploma thesis: “Outcome of Growth Hormone Replacement on Children with Growth Hormone Deficiency”, Iasi, Romania, 2014.

Dissertation: “Chemokine Expression in Benign and Malignant Adrenal Tumors”, University Hospital of Würzburg (in progress)

Research theme: Adrenal insufficiency     

  1. Registry for patients with chronic adrenal insufficiency: prospective and retrospective analysis of morbidity/comorbidities/mortality, adrenal crises, patient subpopulations and quality of life; establishing new parameters/algorithms to assess the quality of the replacement therapy and provide a personalized therapy
  2. Assessment of tissue sodium content by 23Na-MRI in patients with primary adrenal insufficiency
  3. Extent of liver fatty degeneration and liver fibrosis under replacement therapy with glucocorticoids in adrenal insufficiency (coordinated by University Hospital Frankfurt)


Fenske W, Refardt J, Chifu I  et al. A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus. N Engl J Med 2018; 379:428-439. doi: 10.1056/NEJMoa1803760    

Refardt J, Sailer CO, Winzeler B, Betz MJ, Chifu I, Schnyder I, Fassnacht M, Fenske W, Christ-Crain M. FGF-21 levels in polyuria-polydipsia syndrome. Endocr Connect. 7(12):1501-1506. doi: 10.1530/EC-18-0469.

2018: Poster prize of the DGE, 13. Deutsche Nebennierenkonferenz der Sektion Nebenniere, Steroide und Hypertonus 2018