Our Clinician Scientists Profile: Wulf Tonnus

Wulf Tonnus, Clinician Scientist, Adrenal Research CRC/TRR205

Wulf Tonnus

Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden

State examination: 06/18 in Kiel

Promotion:  submitted

Research Theme: Clinically relevant regulated cell death, especially ferroptosis

CRC/TRR 205 projects: 


1          Greve, A. S.et al.P2X1, P2X4, and P2X7 Receptor Knock Out Mice Expose Differential Outcome of Sepsis Induced by alpha-Haemolysin Producing Escherichia coli. Frontiers in cellular and infection microbiology7, 113, doi:10.3389/fcimb.2017.00113 (2017).

2          Martens, S.et al.Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury. Cell Death Dis8, e2904, doi:10.1038/cddis.2017.298 (2017).

3          Sarhan, M., Land, W. G., Tonnus, W., Hugo, C. P. & Linkermann, A. Origin and Consequences of Necroinflammation. Physiological Reviews98, 727-780, doi:10.1152/physrev.00041.2016 (2018).

4          Tonnus, W., Al-Mekhlafi, M., Gembardt, F., Hugo, C. & Linkermann, A. Assessment of In Vivo Kidney Cell Death: Glomerular Injury. Methods in molecular biology (Clifton, N.J.)1857, 145-151, doi:10.1007/978-1-4939-8754-2_14 (2018).

5          Tonnus, W., Al-Mekhlafi, M., Hugo, C. & Linkermann, A. Assessment of In Vivo Kidney Cell Death: Acute Kidney Injury. Methods in molecular biology (Clifton, N.J.)1857, 135-144, doi:10.1007/978-1-4939-8754-2_13 (2018).

6          Tonnus, W., Gembardt, F., Hugo, C. & Linkermann, A. Die later with ESCRT! Oncotarget8, 41790-41791, doi:10.18632/oncotarget.17903 (2017).

7          Tonnus, W.et al.The clinical relevance of necroinflammation—highlighting the importance of acute kidney injury and the adrenal glands. Cell Death & Differentiation, doi:10.1038/s41418-018-0193-5 (2018).

8          Tonnus, W., Hugo, C. & Linkermann, A. Gimme a complex! Resident mononuclear phagocytes in the kidney as monitors of circulating antigens and immune complexes. Kidney international91, 267-269, doi:10.1016/j.kint.2016.10.029 (2017).

9          Tonnus, W. & Linkermann, A. “Death is my Heir”–Ferroptosis Connects Cancer Pharmacogenomics and Ischemia-Reperfusion Injury. Cell chemical biology23, 202-203, doi:10.1016/j.chembiol.2016.02.005 (2016).

10       Tonnus, W. & Linkermann, A. The in vivo evidence for regulated necrosis. Immunological reviews277, 128-149, doi:10.1111/imr.12551 (2017).

11       von Mässenhausen, A.et al.Phenytoin inhibits necroptosis. Cell Death & Disease9, 359, doi:10.1038/s41419-018-0394-3 (2018).

12       von Massenhausen, A., Tonnus, W. & Linkermann, A. Cell Death Pathways Drive Necroinflammation during Acute Kidney Injury. Nephron140, 144-147, doi:10.1159/000490807 (2018).

4x scholarship of Germany 2013-2017