Project A02

The impact of hypoxia pathway proteins on the adrenergic response in the adrenal gland and beyond 

Principal Investigators

Prof. Dr. med.
Ali El-Armouche

Technische Universität Dresden

Universitätsklinikum Carl Gustav Carus

Institute of Pharmacology and Toxicology


Prof. Dr., PhD
Ben Wielockx

Technische Universität Dresden

Universitätsklinikum Carl Gustav Carus

Institute of Clinical Chemistry and Laboratory Medicine


Wissenschaftliche Mitarbeiter:innen

Scientific Staff

Deepika Watts – Postdoc
Mangesh Jaykar – PhD student
Anja Krüger – TA

Project Description

During the second funding period we will continue our research related to the impact of hypoxia-pathway proteins (HPPs) in the HPA axis and sympathetic and adrenal medullary systems. Based on our unique collection of adrenal gland-specific HPP transgenic mouse lines (Tab. 1) we aim to further delineate the consequences of chronically altered steroidogenesis and modified responses of chromaffin cells due to changes in the PHD-HIFα axis (Fig. 6). Addressing these complex interplays requires merging expertise in haematopoiesis, hypoxia pathways, adrenergic signalling and the adrenal gland; this will be brought together by the Wielockx group (Hypoxia-pathway proteins/ haematopoiesis/ inflammatory models), the El-Armouche group (SNS/ beta-adrenergic signalling) and the close collaborations established with a number of other groups


(I) Determine the impact of chronic exposure to systemic high/low glucocorticoid levels in adrenocortical-related HPP transgenic mice during haematopoiesis/erythropoiesis and local immune response.

(II) Characterise the consequences of modulating central HPPs in chromaffin cells in mice.

(III) Define the potential role of β2AR on haematopoietic cell lineages during (stress) haematopoiesis/erythropoiesis.

Publications (CRC/TRR 205 Publications included)