The physiology and pathophysiology of aldosterone production in the pig
Principal Investigators
Prof. Dr. med. vet.
Eckhard Wolf
Ludwig-Maximilians-Universität Munich
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre and Department of Veterinary Sciences
ewolf[at]genzentrum.lmu.de
PD Dr. med. vet.
Elisabeth Kemter
Ludwig-Maximilians-Universität Munich
Institute of Molecular Animal Breeding and Biotechnology, Gene Centre and Department of Veterinary Sciences
kemter[at]genzentrum.lmu.de
PhD
Tracy Ann Williams
Ludwig-Maximilians-Universität Munich
Medizinische Klinik und Poliklinik IV
tracy.williams[at]med.uni-muenchen.de
Aims
(I) Identify biological mechanisms that regulate aldosterone production in the pig adrenal cortex
(II) Generate a pig transgenic model of PA by integration of a KCNJ5 mutation
Publications
2020
Vohra T*, Kemter E*, Sun N, Dobenecker B, Hinrichs A, Burrello J, Gomez-Sanchez EP, Gomez-Sanchez CE, Wang J, Kinker I, Teupser D, Fischer K, Schnieke A, Peitzsch M, Eisenhofer G, Walch A, Reincke M, Wolf E*, Williams TA*. Effect of dietary sodium modulation on pig adrenal steroidogenesis and transcriptome profiles. Hypertension 2020;76(6):1769-1777. doi: 10.1161/HYPERTENSIONAHA.120.15998