Project B19

The physiology and pathophysiology of aldosterone production in the pig

Principal Investigators

Prof. Dr. med. vet.
Eckhard Wolf

Ludwig-Maximilians-Universität Munich

Institute of Molecular Animal Breeding and Biotechnology, Gene Centre and Department of Veterinary Sciences

ewolf[at]genzentrum.lmu.de

PD Dr. med. vet.
Elisabeth Kemter

Ludwig-Maximilians-Universität Munich

Institute of Molecular Animal Breeding and Biotechnology, Gene Centre and Department of Veterinary  Sciences

kemter[at]genzentrum.lmu.de

PhD
Tracy Ann Williams

Ludwig-Maximilians-Universität Munich

Medizinische Klinik und Poliklinik IV

tracy.williams[at]med.uni-muenchen.de

Aims

(I) Identify biological mechanisms that regulate aldosterone production in the pig adrenal cortex

(II) Generate a pig transgenic model of PA by integration of a KCNJ5 mutation

Publications

2020

Vohra T*, Kemter E*, Sun N, Dobenecker B, Hinrichs A, Burrello J, Gomez-Sanchez EP, Gomez-Sanchez CE, Wang J, Kinker I, Teupser D, Fischer K, Schnieke A, Peitzsch M, Eisenhofer G, Walch A, Reincke M, Wolf E*, Williams TA*. Effect of dietary sodium modulation on pig adrenal steroidogenesis and transcriptome profiles. Hypertension 2020;76(6):1769-1777. doi: 10.1161/HYPERTENSIONAHA.120.15998