Project B20

Targeting ferroptosis in adrenocortical carcinoma (ACC): from basic mechanisms to novel treatments

Principal Investigators

Dr.
Isabel Weigand  


Ludwig-Maximilians-Universität Munich

Medizinische Klinik und Poliklinik IV

isabel.weigand[at]med.uni-muenchen.de

Dr.
José Pedro Friedmann-Angeli

Universität Würzburg

Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging

pedro.angeli[at]virchow.uni-wuerzburg.de

Dr. rer. nat.
Matthias Kroiss


Ludwig-Maximilians-Universität Munich

Medizinische Klinik und Poliklinik IV

Matthias.Kroiss[at]med.uni-muenchen.de

Aims

(I) Explore the function and therapeutic potential of FSP1 in ACC

(II) Elucidate selenium uptake and metabolism in adrenocortical cells in order to develop treatment strategies mimicking GPX4 inhibition.

(III) Characterise the immunomodulatory effects of ferroptosis in ACC

Publications (CRC/TRR205 included)