Targeting ferroptosis in adrenocortical carcinoma (ACC): from basic mechanisms to novel treatments
Principal Investigators
Dr.
Isabel Weigand
Ludwig-Maximilians-Universität Munich
Medizinische Klinik und Poliklinik IV
isabel.weigand[at]med.uni-muenchen.de
Dr.
José Pedro Friedmann-Angeli
Universität Würzburg
Rudolf Virchow Zentrum, Center for Integrative and Translational Bioimaging
pedro.angeli[at]virchow.uni-wuerzburg.de
Dr. rer. nat.
Matthias Kroiss
Ludwig-Maximilians-Universität Munich
Medizinische Klinik und Poliklinik IV
Matthias.Kroiss[at]med.uni-muenchen.de
Aims
(I) Explore the function and therapeutic potential of FSP1 in ACC
(II) Elucidate selenium uptake and metabolism in adrenocortical cells in order to develop treatment strategies mimicking GPX4 inhibition.
(III) Characterise the immunomodulatory effects of ferroptosis in ACC
Publications (CRC/TRR205 included)